This paper introduces a design method of multi-channel active low-pass filter based on MAX274 chip,and low-pass filter frequency response curve is obtained and verified by Matlab simulation. It’s observed that the low-pass filter’s filtering and gain performance in the corresponding frequency band is fine. This design is small in size,monolithic and easy to debug. When used in underwater acoustic measurement device of a large depth submersible project,this device can realize the monitoring of target signal under the deep sea background and long-term fixed-point acquisition of marine environmental noise.