The paper studied acoustic-structure coupling analysis to simulate the underwater explosion shock on a cylindrical shell. The underwater explosions models for permeable cylindrical shell and the sealed cylindrical shell were analyzed using the large scale finite element analysis program ABAQUS. The calculations of finite element analysis is compared with the theoretical ones. The results show that this numerical analysis method can simulate the real behaviors of a cylindrical shell underwater explosion,and meet engineering requirements. Besides, under the same underwater explosion action,the permeable cylindrical shell has better anti-explosion and shock resistance performance compared to the sealed one.