With the expansion of UAV' s operational application, it will become an important method in the future aerial an-tisubmarine by cooperative operation with manned patrol aircraft and UAVs. Based on process and task of cooperative antisubmarineof antisubmarine patrol aircraft and UAVs, this paper proposes cooperative configuration principle of antisubmarine patrol aircraftand UAVs, and determines the method of zone setting. The simulation results verify the feasibility and practicability of the coopera-tive antisubmarine method and provide a reference for cooperative escort in antisubmarine operation of anti-submarine patrol aircraftand UAVs , which provides a valuable reference for UAVs playing an important role in the future antisubmarine combat.